Wins 12/12 supported alleles vs NetMHCpan-4.2 Bootstrap p ≈ 0 86% novel test pairs

Predict MHC-I peptide binding and presentation

Head-to-head evaluated against the pinned NetMHCpan-4.2c executable on 496,240 post-cutoff mono-allelic candidates spanning 3 PRIDE studies and 13 HLA alleles.

Primary result: per-allele macro AUROC 0.844 vs NetMHCpan-4.2c 0.816 (Δ = +0.028). Pooled paired Δ = +0.0113 [+0.0094, +0.0134], bootstrap p ≈ 0. Wins on every supported allele. See the interactive dashboard →

Predict a single peptide + HLA

Paste an 8–14mer peptide (20 standard AAs) and a supported HLA-I allele. Output: binding-affinity (BA) and presentation (EL) probabilities. Threshold 0.5 for the binary label (≈ 500 nM for BA).

Batch prediction CSV upload, up to 100,000 rows

Upload a CSV with columns peptide,hla_allele. Response is a scored CSV with ba_score, el_score, ba_binder, el_presented, valid_peptide, supported_allele columns appended.

Example: example.csv